Endocrine Abstracts

Background: Accumulating evidence indicates the presence of bidirectional cross-talks between the endocrine and the immune system. However, no data are available on the influence of either the thyroid hormones or TSH within the normal range on the immune cell function in healthy humans.Aim: To comprehensively investigate the effects of the hypothalamic-pituitary-thyroid axis on the variation of immune responses in a cohort of healthy volunteers.<p cl...

Objectives: Anaplastic thyroid carcinoma (ATC) is one of the malignancies with the highest mortality among all cancers. Immune cells are highly abundant in ATC tumors and increased infiltration with tumor-associated macrophages is associated with decreased survival. We hypothesize that systemic inflammatory markers are also associated with survival in patients with ATC and are more elevated in ATC compared to poorly differentiated thyroid carcinoma (PDTC).<p class="abstext...

Background: Tumor-associated macrophages (TAMs) with dysregulated inflammatory phenotypes play a key role in carcinogenesis. In thyroid carcinoma (TC), excessive release of proinflammatory cytokines decreases the expression of sodium-iodine transporter and inflammation potentiates tumor progression.Aim: To assess the impact of TC cells on the functional reprograming of TC-induced macrophages at the level of transcriptome and metabolic pathways, and asses...